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Researchers at NYU’s Grossman School of Medicine, in NYC, have identified a specific microbe in commensal gut bacteria that blooms and appears to both trigger and drive lupus flares and lupus nephritis in those with genetic predispositions.
Lupus flare-ups strongly linked to specific bacterial growth in gut
Excerpts:
New research from NYU Grossman School of Medicine shows that bacterial blooms of the gut bacterium Ruminococcus blautia gnavus occurred at the same time as disease flare-ups in five of 16 women with lupus of diverse racial backgrounds studied over a four-year period.
“Such future treatments for lupus, especially lupus nephritis, could potentially decrease the use of drugs designed to dampen the immune system and instead promote the use of less-toxic antibacterial agents, probiotics or dietary regimens that prevent imbalances such as Ruminococcal blooms in the local gut bacterial population, or microbiome,” said Silverman, the Mamdouha S. Bobst Professor of Internal Medicine in the Departments of Medicine and Pathology at NYU Langone Health.
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