Recommended Reading and ViewingMediaJournal ArticlesOther Useful BooksUseful Contacts

Recommended Reading and Viewing

Pulsed Antibiotic Protocol and Rationale

Sometimes referred to as the Historical Protocol, this approach by Dr. Brown was based on the anti-microbial effects of the tetracyclines: tetracycline, doxycycline and, later, minocycline, which became the tetracycline of choice due to its superior tissue penetration and ability to cross the blood-brain barrier.

Brown opted to treat in pulsed doses due to the slow replication of mycoplasma (his primary area of focus), because it’s an organism that doesn’t require a constant attack by the antibiotic. He also titrated the dose to individual patient tolerance, given that many people with inflammatory forms of arthritis can sometimes experience an extreme Jarisch-Herxheimer reaction that is counter-productive, as severe inflammation prevents the antibiotic from reaching its target.

The protocol that follows was compiled in 1998 as an online resource for patients and physicians.
Click here to read about this protocol and rationale
Printable PDF of Historical Protocol as compiled in 1998



Review of Daily Antibiotic Protocol (‘Harvard Protocol’)

The material at the link below comprises a review of what has become known as The Harvard Protocol. The Harvard Protocol is so named because of the NIH-sponsored MIRA (Minocycline in Rheumatoid Arthritis) trials which were run out of Beth Israel Deaconess Hospital in Boston in 1995.

In these trials, Minocycline was researched as to whether it is a safe and effective DMARD (Disease-Modifying Anti-Rheumatic Drug), rather than for its anti-microbial properties.
Click here to read about this protocol and rationale
Printable PDF of Current Protocols Review as compiled in 1998



The New Arthritis Breakthrough by Henry Scammell

Includes the original book by Dr. Thomas McPherson Brown, The Road Back

The book that makes the case for antibiotics in rheumatic disease, The New Arthritis Breakthrough opens with detailed analyses of the major clinical studies, proving minocycline to be the safest, most effective therapy ever tested in these applications. Also included is the full text of Dr. Thomas McPherson Brown’s landmark work, The Road Back, plus a bibliography of antibiotic research, and candid photographs of patients in activities of daily living, astonishing visual contrasts to their previous case histories.

“This unique, groundbreaking book contains lifesaving information”
The Editors, Total Health

“A must read … new hope for rheumatoid arthritis, Lupus and scleroderma”
Julian Whitaker, MD, Health & Healing

“Indispensable … exciting, readable – the biography of a treatment that works”
A. Robert Franco, MD, Arthritis Center of Riverside (CA)

Generally available in hard cover, paperback or Kindle versions
Click Here to purchase from Amazon



Scleroderma: The Proven Therapy That Can Save Your Life by Henry Scammell

The study described in this book and reported in the medical journal, The Lancet, is a testament to the success of a collaborative effort to solve one of medicine’s oldest and most pernicious mysteries. Performed at Harvard Medical School under the joint sponsorship of Road Back Foundation and the National Institutes of Health, its results offer unprecedented new hope for the 400,000+ Americans afflicted by this slow, agonizing, often fatal disease. Decide for yourself why the therapy attracted so much resistance among the defenders of the status quo, at the same time as the Harvard study was reported by CNN to viewers around the world as a major breakthrough.

Generally available in hard cover, paperback or kindle versions

Click Here to purchase from Amazon


Dr. Brown Video Documentary

To view Dr Brown’s documentary, click on the title:
The Antibiotic Approach to Rheumatoid Arthritis

Note: please allow time for this video to buffer before playing. You will need the latest Adobe Flash Player to view (free download)

Antibiotic Therapy For Rheumatoid Arthritis – An Important Therapeutic Alternative Booklet (Click Here).

This PDF booklet was originally published in 1985 by The Arthritis Institute of the National Hospital for Orthopedics and Rehabilitation. It is a primer on the life’s work of Dr. Thomas McPherson Brown and his key research associates, all of whom were committed to identifying the underlying infectious causes of rheumatic diseases. In it, you will find information on the history, the scientific rationale, the faces behind the research and the originators of the Antibiotic Protocol (AP) treatment option for rheumatic patients.

Harris Poll Survey Results

Survey Reveals Common, Low Cost Antibiotic Therapy May Have Considerable Benefits for Rheumatoid Arthritis (RA).

Survey shows substantial improvements in disease, reduction in pain, severity of condition and better quality of life as reported by rheumatoid arthritis and scleroderma patients. Key findings include the impact of antibiotic therapy versus traditional medication for RA in the overall management of the disease, as well as its effect on pain, quality of life and tolerability.

Harris Poll Press Release – click here

Review Entire Harris Poll Survey 80 pages
File will open in a new window. Please allow a few minutes to download.

Article by David E. Trentham, M.D., “Antibiotic Therapy for Rheumatic Disease. You know where we have been; so where are we now?

Presentation by Thomas McPherson Brown, M.D., “Guidelines For Infectious Hypersensitivity Approach To The Treatment Of Rheumatoid Arthritis