Gum Disease; a causative pathway in anti-CCP-positive RA

[Maz]

Study suggests causative pathway between gum disease and rheumatoid arthritis

Anti-citrullinated protein antibodies (ACPAs) are found in the blood of most patients with RA. They are correlated so tightly that ACPAs detected in the blood are the best early detection tool for future RA pathology as they can pre-date clinical diagnosis by several years. Gum disease is specifically more common in individuals with RA who also have ACPAs in their blood.

In a study led by Stanford University, researchers wanted to investigate whether these overlapping observations could be better connected.

Direct link to study:

SCIENCE TRANSLATIONAL MEDICINE
22 Feb 2023
Vol 15, Issue 684
DOI: 10.1126/scitranslmed.abq8476:

Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis

[Author]

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