I’m not sure when the best time is to take it. With the Serrazimes they must be taken two hrs before food. I shall have to research more into what helps remove biofilm. I’m not sure what the acidity of the ACV would do to the antibiotic. So I recommend taking it a couple of hrs before the Antibiotic. My husband has a range of anti inflammatory supplements that he takes early morning and a couple of hrs before dinner and includes the Serrazime in that. He takes the Antibiotic after dinner.