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hi , would anyone know if sinus/fungal infection in sinuses, cause a raised eosinophil blood test. the specialist is blaming the mtx. but i have been wondering lately if it coul be sinus related. i also have a nasal polyp , which i have had for years. and have had stuffy nose as long as i can remember, and have used all kinds of sprays over the years. i have had a c.t. scan and it said no signs of sinus infection / or deviated septum. i dont really know how to tell if it is fungal.? i would appreciate any thoughts..kind regards..di. p.s. of a morning i cough up a lot of yellow phlegm , but only in the first hour of rising not during the day, and when i blow my nose nothing comes out?
@dianne-sunshinecoast wrote:
hi , would anyone know if sinus/fungal infection in sinuses, cause a raised eosinophil blood test. the specialist is blaming the mtx. but i have been wondering lately if it coul be sinus related. i also have a nasal polyp , which i have had for years. and have had stuffy nose as long as i can remember, and have used all kinds of sprays over the years. i have had a c.t. scan and it said no signs of sinus infection / or deviated septum. i dont really know how to tell if it is fungal.? i would appreciate any thoughts..kind regards..di. p.s. of a morning i cough up a lot of yellow phlegm , but only in the first hour of rising not during the day, and when i blow my nose nothing comes out?
Dianne,
A search using your words above found the following on Cleveland Clinic Med Ed site, and am copying/pasting this excerpt:
From: http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/allergy/rhino-sinusitis/A distinct entity, allergic fungal sinusitis (AFS), occurs in immunocompetent patients and results from an immunologic reaction to fungi that colonize the sinuses.11 Most people tolerate exposure to mold spores in the air because they are ubiquitous in our environment. However, people with AFS develop a hypersensitivity reaction involving an intense eosinophilic inflammatory response to the fungus that has colonized the sinuses. Common fungi associated with this syndrome include Bipolaris specifera and Aspergillus, Curvularia, and Fusarium species.11 This is an allergic noninvasive response to the fungus that should be distinguished from invasive fungal sinusitis, which is more common in diabetic and immunocompromised patients. The diagnostic criteria for AFS include findings of chronic sinusitis on computed tomography (CT) of the sinuses (such as mucosal thickening, opacification, polyps, and high-intensity signaling from the high protein content in the mucus) or low signaling of fungal concretions in sinus cavities on MRI. On sinus culture, fungi can be isolated with associated allergic mucin, which is mucus loaded with degranulated eosinophils. Allergy skin testing can verify that these patients have an immunoglobulin E (IgE)-mediated reaction to molds.
Also, several years ago, Mayo Research published a statement about most sinus problems being fungal related. A search found this, too. http://www.sinuses.com/fungal.htm
Good luck with finding the cause of your problem, and getting it a thing of the past.
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