doxylin reaction or?

[dianne-sunshinecoast]

hi all- since i started the doxylin a week ago , 100mg every day , i have been having chills, blurred vision, racing heart, dizziness. mainly the last few days. i am wondering if it is the doxylin alone or an interaction with the methotrexate? i did google search and found that doxycycline can increase the side effects of methotrexate. just wondering if anyone has any thoughts on this. ? i will ask the chemist today, but as its friday i dont hold out much hope for seeing a doctor. i would appreciate any thoughts. …kind regards ..di.

[Maz]

@dianne-sunshinecoast wrote:

hi all- since i started the doxylin a week ago , 100mg every day , i have been having chills, blurred vision, racing heart, dizziness. mainly the last few days. i am wondering if it is the doxylin alone or an interaction with the methotrexate? i did google search and found that doxycycline can increase the side effects of methotrexate. just wondering if anyone has any thoughts on this. ? i will ask the chemist today, but as its friday i dont hold out much hope for seeing a doctor. i would appreciate any thoughts

Hi Di,

According to Dr. T, who ran the MIRA trials, minocycline (and doxy) can be taken concomitantly alongside conventionally-used rheumatic drugs without a problem. Of course, it’s impossible to predict who may be allergic to the tetras or have some unusual side-effect (and with your esoinophilia issue, I suspect that you may want to watch this lab while undergoing therapy, though elevations in labs are common with herxing, too). Generally, however, the tetras are very well tolerated by most people, even when taken in combination with methotrexate. So, although this is just a fellow patient opinion, providing you are not having some type of allergic reaction, then my money is on your symptoms being herx-related.

Here is the write-up that Dr. T provided on this topic in last summer’s eBulletin:

https://www.roadback.org/EmailBlasts/ebulletin_fall10.html

See article entitled: “Antibiotic Therapy for Rheumatic Disease

[dianne-sunshinecoast]

hi maz, thank you for your reply, i have had my chemist try to get in touch with my g.p. and rheumatologist. and speak on my behalf as i am not very well . i will look up the threads you put up for a bit later as not up to it at the moment. ..the chemist rang and said she got in touch with the g.p., and was utterly shocked as he didnt want to know as he was too busy. it is crisis point in regional areas as far as gps and specialists go in qld anyway. so will see if the specialist responds.. very much appreciate your rsply..kind regards ..di.

[Maz]

@dianne-sunshinecoast wrote:

hi maz, thank you for your reply, i have had my chemist try to get in touch with my g.p. and rheumatologist. and speak on my behalf as i am not very well . i will look up the threads you put up for a bit later as not up to it at the moment. ..the chemist rang and said she got in touch with the g.p., and was utterly shocked as he didnt want to know as he was too busy. it is crisis point in regional areas as far as gps and specialists go in qld anyway. so will see if the specialist responds.. very much appreciate your rsply..kind regards ..di.

Di, no worries, my heart goes out to you in all respects….please feel better soon!!!

[lynnie_sydney]

Di – whilst it is smart to check things out with your doc, my best guess is that 100mg every day of the doxy is too much for you and that you are likely hypersensitive and having a very big herx response. If it were me, I’d stop for around a week then re-introduce on fewer days per week (maybe 2) and, possibly at a lower dose to see how I tolerate it.

Be well! Lynnie

Palindromic RA 30 yrs (Chronic Lyme?)
Mino 2003-2008 100mg MWF - can no longer tolerate any tetracyclines
rotating abx protocol now. From Sep 2018 MWF - a.m. Augmentin Duo 440mg + 150mg Biaxsig (roxithromycin). p.m. Cefaclor (375mg) + Klacid 125mg + LDN 3mg + Annual Clindy IV's
Diet: no gluten, dairy, sulphites, low salicylates
Supps: 600mg N-AC BID, 1000mg Vit C, P5P 40mg, zinc picolinate 60mg, Lithium orotate 20mg, Magnesium Oil, Bio-identical hormones (DHEA + Prog + Estrog)

[dianne-sunshinecoast]

lynnie-maz, just a quick post still not feeling too well, i had a call from the rheumatologists office , and instructed to stop doxy, and they are sending me a pathology form in the mail , not sure what the tests are , must be different to the full test i have each month to monitor methotrexate? the chemist said even though i have stopped the doxy i can still be having a reaction – i am extremely tired and weak as well as the other symptoms i posted , plus feel like i am getting a bladder infection? appreciate your replies…kind regards..di.

[hbell]

Hi Di, I would agree with what the others have said. I am currently on 17.5mg MTX and 100mg Doxy 3 times a week. I have been on the doxy since Feb 2010 and finally reached the 17.5 mg dose of MTX in May 2011. I have had no issues. It certainly sounds that 100mg doxy a day is way too much if you have only been on it a week or so? Also how long have you been taking MTX. Either way, I hope you find a resolution and get better soon.

[dianne-sunshinecoast]

hi hbell, i have been on mtx 3.5yrs. appreciate your reply. the trouble with adjusting the dosage of doxy is that the rheumatologist is not open to lyme or antibiotic therapy for r.a.,it is getting that way where i live , the doctors will only agree to see you if you see them exclusivly, once you start trying to get another opinion or b,tests from other docs they are refusing to treat you. without going into detail, these are my only options at the moment.and that is to stay in my local area. all the best to you…kind regards ..di.

[hbell]

Hi Di,
My local doc sort of has an idea that I’m following AP, but we don’t discuss it anymore. an interstate doc put me on Ap. My Rheumy has no idea and I have no intentions of telling her either. We are behind the eight ball in that a lot of docs and rheumys don’t believe in AP. Obviously it wasn’t an AP doc who prescribed the doxy and dose?? I reckon do what Lynnie said and stop it and restart when you’ve washed this lot out of your system. You can break the tabs in half and possibly start at 50mg twice a week initially. also a couple of my friends who do not have auto immune issues had at some time taken doxy and had adverse reactions and stopped immediately. from memory I think one said something about her eyesight, but I’d have to double check that. Cheers…

[dianne-sunshinecoast]

hi hbell, i appreciate your reply. the problem with continuing with doxy and not telling the doctors is , when i have my monthly blood tests and the esr – crp etc have increased or their are other abnormalities, they assume , i would think that it is the mtx , and adjust the dose , or want to change the mtx or whatever one is on, thinking that med. is the offender and give another , to me their eventually be a day of reckoning so to speak? …as a herx will give a high reading in those areas i would think? i dont know a lot how things work but when i tried the minomycin that is what happened and that doctor panocked and washed her hands of me. .. it is a challenge thats for sure 😕 all the best …kind regards ..di.

[dianne-sunshinecoast]

i just received a pathology request form from the rheumatologist, i am to have a LYME SEROLOGY / BORRELIA PCR , post 4wks antibiotics. the pathology lab. is called-HEALTHSCOPE PATHOLOGY- and then they send it to melbourne somewhere? i dont know if any of you have heard of this lab? i will keep in touch as to what the results are..kind regards ..di.

[Krys]

Hi Di,
I don’t know anything about this test.
I’m writing to ask if you are are familiar with Stephen Harrod Buhner’s “Healing Lyme. Natural Healing and Prevention of Lyme Borreliosis and Its Coinfections”?

You’ve had so many challenges on your roadback to health….In May/June I meant to suggest that you acquaint yourself with some of the herbs described in the book as they have strong organ protective function while targeting all kinds of unwelcome organisms. I checked Australian stores to see if the herbs would be accessible. Regular herbal stores carry some, but the prices are abnormally high. I checked Chinese Medicine herbal stores and they do carry them but they show up only under Chinese names. The cheapest one only sold to TCM practitioner (maybe after calling them they would reconsider?) but there was another one open to the public. I lost the detailed reply before I could post it and had no energy to start over again.
So the present reply is something you should have received from me before you knew you had Lyme!

I’m very, very happy I’m combining herbal (Buhner’s) protocol for Lyme with antibiotics.
I’ve had organ involvement with severe at times inflammation exacerbated by die off. Intense detox took care of it wonderfully for a while….and then while feeling good I started traveling and had no time for detox, did not keep the diet…and things went bad. I just could not see how I would possibly be able to keep taking abx when kidneys, liver and pancreas were getting progressively worse and my best detoxification (the one that worked like a miracle) was not appropriate for me any more.

I reread the book, my LLMD OK-ed the herbs and after a few weeks I started feeling really good. It takes a while to build up the dosage to the full protocol, though I’m staying at a slightly lower dosage as I do combine it with abx. I think it is also easier on my organs to take smaller amount of abx. The herbs have a potentiating effect on abx, so the dosage is cut in half.
In my understanding the combination of herbs and abx works the best. But there are people who only use Buhner’s herbal protocol, usually when they cannot take abx or after they took abx for a while and do not want to keep taking them for years.

My herx, whenever present, is milder; the herbs are helping with the detox, too. Not enough to completely stop detoxing, but there is no urgent need any more to do it daily. Once in a few days’ time is enough for me now. The organs are not perfect: if I omit detox for a longer period of time, the kidneys and liver and lately the heart make their presence felt. But it’s all very slight, not a major problem I had before. And if I’m mindful to take a toxin binder at least every few days, and if I keep the diet, I feel just wonderful!

I’m not trying to convince you try it, but I think maybe you will find some solutions in the book once you read it?
May your journey become smooth and may you feel wonderful any time soon, Krys

[dianne-sunshinecoast]

hi krys-what an amazing lot of people you all are to go to so much trouble when you are not well yourselves 🙁 i dont know the book krys? all those things you are suggesting sound good. but due to certain situations in my life i have been left like the proverbial church mouse, i understand thats my lot and i am trying to do the best i can 🙂 as well as the health challenge i am having a lot of other challenges at the moment( paying of some life debt no doubt ), still have to deal with it the best i can.doing the very best i can , and trusting it is all going to turn out ok soon. , thank you so much for your long post…kind regards di. take care of yourself.

[dianne-sunshinecoast]

@Maz wrote:

@dianne-sunshinecoast wrote:

hi all- since i started the doxylin a week ago , 100mg every day , i have been having chills, blurred vision, racing heart, dizziness. mainly the last few days. i am wondering if it is the doxylin alone or an interaction with the methotrexate? i did google search and found that doxycycline can increase the side effects of methotrexate. just wondering if anyone has any thoughts on this. ? i will ask the chemist today, but as its friday i dont hold out much hope for seeing a doctor. i would appreciate any thoughts

Hi Di,

According to Dr. T, who ran the MIRA trials, minocycline (and doxy) can be taken concomitantly alongside conventionally-used rheumatic drugs without a problem. Of course, it’s impossible to predict who may be allergic to the tetras or have some unusual side-effect (and with your esoinophilia issue, I suspect that you may want to watch this lab while undergoing therapy, though elevations in labs are common with herxing, too). Generally, however, the tetras are very well tolerated by most people, even when taken in combination with methotrexate. So, although this is just a fellow patient opinion, providing you are not having some type of allergic reaction, then my money is on your symptoms being herx-related.

Here is the write-up that Dr. T provided on this topic in last summer’s eBulletin:

https://www.roadback.org/EmailBlasts/ebulletin_fall10.html

See article entitled: “Antibiotic Therapy for Rheumatic Disease

[lynnie_sydney]

i just received a pathology request form from the rheumatologist, i am to have a LYME SEROLOGY / BORRELIA PCR , post 4wks antibiotics. the pathology lab. is called-HEALTHSCOPE PATHOLOGY- and then they send it to melbourne somewhere?

Hi Di – I would try emailing Mualla McManus President of Karl McManus Foundation. She will answer and will know if reliable or not. Not only is she advocating for Lyme treatment in Austrralia (her husband died from untreated LD) she is a very knowledgeable woman, a scientist and pharmacist. Here’s the link http://www.karlmcmanusfoundation.org.au/contact-us/

Be well! Lynnie

Palindromic RA 30 yrs (Chronic Lyme?)
Mino 2003-2008 100mg MWF - can no longer tolerate any tetracyclines
rotating abx protocol now. From Sep 2018 MWF - a.m. Augmentin Duo 440mg + 150mg Biaxsig (roxithromycin). p.m. Cefaclor (375mg) + Klacid 125mg + LDN 3mg + Annual Clindy IV's
Diet: no gluten, dairy, sulphites, low salicylates
Supps: 600mg N-AC BID, 1000mg Vit C, P5P 40mg, zinc picolinate 60mg, Lithium orotate 20mg, Magnesium Oil, Bio-identical hormones (DHEA + Prog + Estrog)

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