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I developed some toxicity to minocycline and was advised to switch to Doxycycline by Dr. S. I’ve been on mino since 11/09 with great results–that is, my symptoms of SD are completely gone with the exception of some residual stiffness in the PIP joints of my fingers. So, as you can imagine, I was very reluctant to discontinue the mino. I had developed hyperpigmentation with mino (no big deal) but then began to notice a blue spot in both eyes and on other areas of skin. So, last Wednesday, I started taking Doxycycline 100 mg BID. Just wondering if anyone else with SD has done this and what your experience was. I have noticed some tingling at night only when I lay down and after taking the doxy–never in the daytime. It’s a mild tingling, but scary never the less. I am considering making some modifications to the dose–i.e., taking mino 200 mg. on MWF and doxy 200 mg. the remainder of the week. From what I have read so far, the mino toxicity seems to be dose related. Any thoughts?
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