Have now been on Minocin 100mg daily for about 3 months I think and it made a big difference, keeping up the inner health plus and also vitamin c for skin discolouration. Even tried some mild excercise and it did not hurt my joints just normal stiffness from being so unfit. Nodules are still there in my hands but no restriction, some limitations of movement in one arm and knee and bottom of feet. Am now thinking of trying Neprinol to clean up the insides but not sure if this is useful or not-bit hard to figure out how to research these things without a chemistry degree. So think I am doing really well but want to be much better and cut back on the anti-biotics. chrysalis