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Recommended Reading and Viewing

Pulsed Antibiotic Protocol and Rationale

Sometimes referred to as the Historical Protocol, this approach by Dr. Brown was based on the anti-microbial effects of the tetracyclines: tetracycline, doxycycline and, later, minocycline, which became the tetracycline of choice due to its superior tissue penetration and ability to cross the blood-brain barrier.

Brown opted to treat in pulsed doses due to the slow replication of mycoplasma (his primary area of focus), because it’s an organism that doesn’t require a constant attack by the antibiotic. He also titrated the dose to individual patient tolerance, given that many people with inflammatory forms of arthritis can sometimes experience an extreme Jarisch-Herxheimer reaction that is counter-productive, as severe inflammation prevents the antibiotic from reaching its target.

The protocol that follows was compiled in 1998 as an online resource for patients and physicians.
Click here to read about this protocol and rationale
Printable PDF of Historical Protocol as compiled in 1998



Review of Daily Antibiotic Protocol (‘Harvard Protocol’)

The material at the link below comprises a review of what has become known as The Harvard Protocol. The Harvard Protocol is so named because of the NIH-sponsored MIRA (Minocycline in Rheumatoid Arthritis) trials which were run out of Beth Israel Deaconess Hospital in Boston in 1995.

In these trials, Minocycline was researched as to whether it is a safe and effective DMARD (Disease-Modifying Anti-Rheumatic Drug), rather than for its anti-microbial properties.
Click here to read about this protocol and rationale
Printable PDF of Current Protocols Review as compiled in 1998



The New Arthritis Breakthrough by Henry Scammell

Includes the original book by Dr. Thomas McPherson Brown, The Road Back

The book that makes the case for antibiotics in rheumatic disease, The New Arthritis Breakthrough opens with detailed analyses of the major clinical studies, proving minocycline to be the safest, most effective therapy ever tested in these applications. Also included is the full text of Dr. Thomas McPherson Brown’s landmark work, The Road Back, plus a bibliography of antibiotic research, and candid photographs of patients in activities of daily living, astonishing visual contrasts to their previous case histories.

“This unique, groundbreaking book contains lifesaving information”
The Editors, Total Health

“A must read … new hope for rheumatoid arthritis, Lupus and scleroderma”
Julian Whitaker, MD, Health & Healing

“Indispensable … exciting, readable – the biography of a treatment that works”
A. Robert Franco, MD, Arthritis Center of Riverside (CA)

Generally available in hard cover, paperback or Kindle versions
Click Here to purchase from Amazon



Scleroderma: The Proven Therapy That Can Save Your Life by Henry Scammell

The study described in this book and reported in the medical journal, The Lancet, is a testament to the success of a collaborative effort to solve one of medicine’s oldest and most pernicious mysteries. Performed at Harvard Medical School under the joint sponsorship of Road Back Foundation and the National Institutes of Health, its results offer unprecedented new hope for the 400,000+ Americans afflicted by this slow, agonizing, often fatal disease. Decide for yourself why the therapy attracted so much resistance among the defenders of the status quo, at the same time as the Harvard study was reported by CNN to viewers around the world as a major breakthrough.

Generally available in hard cover, paperback or kindle versions

Click Here to purchase from Amazon



Dr. Brown Video Documentary

To view Dr Brown’s documentary, click on the title:
The Antibiotic Approach to Rheumatoid Arthritis

Note: please allow time for this video to buffer before playing. You will need the latest Adobe Flash Player to view (free download)