Home Forums General Discussion Sulfasalazine

This topic contains 6 replies, has 3 voices, and was last updated by  aboyer 1 year, 10 months ago.

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  • #456119
    aboyer
    Participant

    I am taking doxycycline 50 mg for RA. I would like to start taking sulfasalazine along with it because of the pain. Is there a best time to take both? I would like advise on how to take the 2. Also, I have taken the doxy at night before and it seems the next day around lunch time I get really fatigued and sleepy. Is this a side effect from the doxy?

    Diagnosed with severe RA 12 years ago
    Tested positive for M. pneumoniae and C. pneumoniae

    Current meds: Kineret 100mg daily, plaquenil 100 mg daily, and just started on minocycline 50 mg m, w, f

    Supplements: fish oil, vitamin b12, folate, b6, iron, NAC, selenium, zinc, vitamin c, and biotin

    #456120
    jasregadoo
    Moderator

    I take Sulfasalazine and Minocycline. I take my Sulfasalazine with breakfast and dinner, and my Minocycline a couple of hours after. I’ve not been on Doxy, but I suspect it’s similar to Mino, and for the first few months I was very tired in the afternoon. I am still not above taking a nap if I need it, but I’ve always been a fan of naps, so it may not be the Mino. I’ve been on Mino for about a year and a half now. Sulfasalazine a bit longer than that.

    #456122
    aboyer
    Participant

    How long did it take to feel some relief from both? I can’t seem to tolerate mino very well. I start getting brain fog and my head feels funny on it.

    Diagnosed with severe RA 12 years ago
    Tested positive for M. pneumoniae and C. pneumoniae

    Current meds: Kineret 100mg daily, plaquenil 100 mg daily, and just started on minocycline 50 mg m, w, f

    Supplements: fish oil, vitamin b12, folate, b6, iron, NAC, selenium, zinc, vitamin c, and biotin

    #456125
    aboyer
    Participant

    I also have a double mthfr mutation, so I’m not sure if that will make a difference with the doxy and sulfasalazine. I do take a folate supplement.

    Diagnosed with severe RA 12 years ago
    Tested positive for M. pneumoniae and C. pneumoniae

    Current meds: Kineret 100mg daily, plaquenil 100 mg daily, and just started on minocycline 50 mg m, w, f

    Supplements: fish oil, vitamin b12, folate, b6, iron, NAC, selenium, zinc, vitamin c, and biotin

    #456126
    jasregadoo
    Moderator

    It took me about 3 months to start feeling a difference. I also had brain fog. I started at 100 mg 2x a day, felt horrible, and cut back to 100mg 1x a day, 3 times a week. Then I gradually increased to 100mg BID.

    I am ignorant of MTHFR, but I know there are others here who know of such things. šŸ™‚

    #456127
    Maz
    Keymaster

    I also have a double mthfr mutation, so Iā€™m not sure if that will make a difference with the doxy and sulfasalazine. I do take a folate supplement.

    Hi aboyer,

    You likely are already aware of this as you’ve been tested for the MTHFR gene mutation, but for others who may be interested, people with the C677T polymorphism are susceptible to methotrexate toxicity. Am guessing this is why you elected to use sulphasalazine instead and use activated folate as a supplement.

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673494/

    Severe, swift onset RA as a result of Lyme disease
    Current Meds: Biaxin (500mg BID), Tetracycline (500mg BID), Tirosint (88mcg), Liothyronine (10 mcg), Compounded Liposomal Artemisinin, LDN (3mg), Topical Progesterone,
    Current Supps: Curcumin, Bovine Colostrum, ALA. NAC, Milk Thistle, Super Liquid Folate/B12/B-Complex, Probiotics, Vit D3
    Supportive Measures: IV Myer's Cocktails, IV Glutathione, FIR Sauna, Gluten-free diet, Gym.

    #456132
    aboyer
    Participant

    Maz, I have a double mutation of C677T so I couldn’t tolerate methotrexate, it would give me bad pvcs. I know that sulfasalazine is a folate inhibitor as well, and really don’t want to take it. I’m just in a lot of pain. I did really well on minocycline when I was first diagnosed 11 year ago, but now even 50 mg gives me problems with head pressure. Do you know if they make minocycline less than 50mg?

    I also read that doxycycline is not supposed to be taken close to b vitamins.

    Diagnosed with severe RA 12 years ago
    Tested positive for M. pneumoniae and C. pneumoniae

    Current meds: Kineret 100mg daily, plaquenil 100 mg daily, and just started on minocycline 50 mg m, w, f

    Supplements: fish oil, vitamin b12, folate, b6, iron, NAC, selenium, zinc, vitamin c, and biotin

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