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    Linda L

    I wonder if anyone has found B12 supplementation to be helpful with pain in RA
    This is the extract from http://www.naturalhealthadvisory.com

    Treatment for fibromyalgia and rheumatoid arthritis

    Methylcobalamin has been shown to reduce chronic pain in fibromyalgia and rheumatoid arthritis. Although the causes of both conditions are uncertain, the restoration of neuron cells is known to improve their symptoms. In one study, patients with fibromyalgia who received 1.5 mg per day of the vitamin experience significantly less pain.[9] This is potentially the result of the repair of small nerve fibers close to the skin.[3] Similarly, nerve regeneration is shown to relieve pain in rheumatoid arthritis, likely due to the stronger nerve fibers being more resistant to irritation from inflamed joints.[7]
    Theysuggest very high doses of B12:

    •For fibromyalgia and rheumatoid arthritis, studies noted clinical benefits using between 1.5 and 6 mg per day.[11] Capsules typically contain between 1 and 5 mg and must be taken at least twice per day to deliver benefits for fibromyalgia and rheumatoid arthritis. Some methyl B12 supplements are designed to be taken sublingually, that is dissolved under the tongue. These can have the added benefit of absorbing directly into the bloodstream.
    •For multiple sclerosis, studies suggest 60 mg per day. Up to 12 capsules per day may be necessary.

    These are all considered to be very high doses and cannot be acquired from normal B12 supplements of cyanocobalamin. As a water-soluble vitamin, methylcobalamin is excreted in urine and cannot accumulate in the body beyond what is naturally stored in the liver, creating little chance that high doses will cause negative side effects.[12]

    Linda L

    RA tried everything: Methotraxate, Arava, Humira. Pneumonia three times. Anemia. Very low iron. Hypothyroidism
    AP from April 2014 till August 2015. No luck.
    Current medications: Natural thyroid, Mobic, LDN, supplements incl. milk thistle, NAC, vitamins and minerals.
    MTHFR heterozygous

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