RA: how long for minocene to work?

[Dunlop321]

Hi

I’ve had RA since 2007. I’ve been on enbrel for much of this time. It worked brilliantly until 18 months ago and my conditions have worsened a lot since.

I’ve started taking minocene on December 1st 2013, 100ml on Monday, wed and fri. My conditions have worsened a lot since I started this dose. I’m continuing to take enbrel, anti inflam drugs, vit D, krill oil and some probiotics.

Does this sound like the Herx reaction?

This extra pain has been with me more or less since I started minocene, however there were one or two good days so far this month. I’ve also been taking a little more wine/beer on account of the holiday season.

Thanks

[JohnnyMax]

@Dunlop321 wrote:

Hi

I’ve had RA since 2007. I’ve been on enbrel for much of this time. It worked brilliantly until 18 months ago and my conditions have worsened a lot since.

I’ve started taking minocene on December 1st 2013, 100ml on Monday, wed and fri. My conditions have worsened a lot since I started this dose. I’m continuing to take enbrel, anti inflam drugs, vit D, krill oil and some probiotics.

Does this sound like the Herx reaction?

This extra pain has been with me more or less since I started minocene, however there were one or two good days so far this month. I’ve also been taking a little more wine/beer on account of the holiday season.

Thanks

Hi,

This could be the initial response to Minocycline, or just a continued deterioration of your RA, hopefully its the former. You may want to cut back for now on the dosing. Was this the dose your doctor recommended? If so consult with him on your condition and perhaps he will also feel a dose adjustment may be in order.

How long have you been taking the Vitamin D? This can in some individuals cause an increase in autoimmune activity.

On the issue of alcohol, never a good thing when you have these type of diseases, so never a bad idea to drop it for now and see if it makes a difference.

Are you following a good anti-inflammatory diet with an emphasis on repairing the gut? Also have you had your hormone levels checked recently, most people with these issues do have hormone issues and can be helped by replacement therapy.

You need a multi pronged approach for best results. These can be tough diseases to shake, but it can be done.

John

[Dunlop321]

Hi John,

Many thanks for your reply.

I’ve been on vit d for 6 months (my levels were extremely low) and yes my doctor prescribed the minocene after trying numerous diets.

I do feel a little more alert although the RA pains have been severe in my shoulders recently as well as spreading into my hips for the first time. I’m hoping that this is the Herx reaction as I imagine my rheumy will put me on some other biological s when I next meet him in mid January.

Paul

[Karel]

@Dunlop321 wrote:

Hi John,

Many thanks for your reply.

I’ve been on vit d for 6 months (my levels were extremely low) and yes my doctor prescribed the minocene after trying numerous diets.

I do feel a little more alert although the RA pains have been severe in my shoulders recently as well as spreading into my hips for the first time. I’m hoping that this is the Herx reaction as I imagine my rheumy will put me on some other biological s when I next meet him in mid January.

Paul

Paul , please keep us (me) posted on your developments. I have been taking MTX for the bigger part of the year with no success and my rheumy wants me to start Enbrel. At the same time I want to start the AP. Very interested to see if and how the AP will work after some years on Enbrel. Which diets did you try and for how long? I don’t much about it yet but I have read some hope giving information about low dose naltroxene. I am not sure how the forum thinks about this treatment. Something else you might want to get more familiar with.

Success,

Karel

[lynnie_sydney]

Paul
Pain in larger joints such as shoulders and hips is not typical of RA and it may be worth considering being tested for Lyme Disease – Igenex the preferred lab for this.

Also a month or so after starting mino is the classic timeframe for a herx to kick in. Detox as much as you can to flush toxins from yr system – includes loads of fresh water n there are many other detox methods cited on this forum if you search that word. You could also consider a weeks washout and restarting at a lower dose on fewer days to begin with if pain becomes intolerable.

Be well! Lynnie

Palindromic RA 30 yrs (Chronic Lyme?)
Mino 2003-2008 100mg MWF - can no longer tolerate any tetracyclines
rotating abx protocol now. From Sep 2018 MWF - a.m. Augmentin Duo 440mg + 150mg Biaxsig (roxithromycin). p.m. Cefaclor (375mg) + Klacid 125mg + LDN 3mg + Annual Clindy IV's
Diet: no gluten, dairy, sulphites, low salicylates
Supps: 600mg N-AC BID, 1000mg Vit C, P5P 40mg, zinc picolinate 60mg, Lithium orotate 20mg, Magnesium Oil, Bio-identical hormones (DHEA + Prog + Estrog)

[Dunlop321]

Lynn,

Many thanks for your reply. Am taking your advice and drinking plenty of water. Will also enquire about Lyme disease but the pain is in very joint, just my hips and shoulders have flared up badly in the last week, which may be the Herx reaction.

Karel,

I was on a sugar free, gluten free alcohol free and free of all processed foods diet, along with daily doses of nystatin for the best part of 6 months. I felt great and it improved my gut, but it did not help my RA so I’ve discontinued.
I will keep you updated on my progress, fingers crossed the minocylene will work.

Paul

[Karel]

@lynnie_sydney wrote:

I was on a sugar free, gluten free alcohol free and free of all processed foods diet, along with daily doses of nystatin for the best part of 6 months. I felt great and it improved my gut, but it did not help my RA so I’ve discontinued.

Same like me, but Nystatin not for 6 months but for 3 weeks followed by 10 days flucazonole (diflucan). Yes, that has given me much more energy. My integrative gastroenterologist (MD) blames the yeast (which has shown up in various stool tests multiple times) and I found some anecdotal references to the same link between yeast and RA. Didn’t work with me either, but may be healing the gut takes longer and takes a more in-depth look at food intolerances (yeah, that’s probably the most difficult part). I was also diagnosed with Entamoeba Histolityca/dispar (but didn’t have the typical symptoms though).

Succes and please keep us informed. Will do the same.

Karel

[lynnie_sydney]

I didnt write the quoted text above – just to clarify. My dietary changes have been VERY helpful in my road to better health

Be well! Lynnie

Palindromic RA 30 yrs (Chronic Lyme?)
Mino 2003-2008 100mg MWF - can no longer tolerate any tetracyclines
rotating abx protocol now. From Sep 2018 MWF - a.m. Augmentin Duo 440mg + 150mg Biaxsig (roxithromycin). p.m. Cefaclor (375mg) + Klacid 125mg + LDN 3mg + Annual Clindy IV's
Diet: no gluten, dairy, sulphites, low salicylates
Supps: 600mg N-AC BID, 1000mg Vit C, P5P 40mg, zinc picolinate 60mg, Lithium orotate 20mg, Magnesium Oil, Bio-identical hormones (DHEA + Prog + Estrog)

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