Betty,
For me Enbrel is instantaneous. But please understand I didn't even take Enbrel until I was 1 1/2 yrs into AP treatment. In addition to antibiotics, I do lots of natural things to combat inflammation such as an anti-inflammatory diet and a host of herbal anti-inflammatories.
Everything I do outside Enbrel does a really good job decreasing my inflammation, but it doesn't eliminate it mine entirely so my AP doctor (who is also a rheumatologist and a lyme literate doctor) finally had to bring Enbrel onboard.
The adjunct therapies most likely are why Enbrel works so well for me. If you have to resort to Enbrel, please be sure you are doing simpler things to also combat inflammation.
Susan