Home › Forums › General Discussion › Potaba for fibrosis
Tagged: scleroderma, antifibrotic, dermatomyositis, fibrosis, morphea, p-aminobenzoate, pemphigus, potaba
- This topic has 7 replies, 4 voices, and was last updated 7 years, 3 months ago by
Denyse.
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July 1, 2012 at 8:37 am #306874
PhilC
ParticipantI recently did some research on this drug and thought I’d post what I found.
Information from the manufacturer:
Potaba ® (Potassium p-Aminobenzoate) – Patient Information
http://www.glenwood-llc.com/potaba.htmlPotaba ® (Potassium p-Aminobenzoate) – Prescribing Information
http://www.glenwood-llc.com/pre-potaba.htmlRelevant research:
A comparison of morphoea and lichen sclerosus et atrophicus in vitro: the effects of para-aminobenzoate on skin fibroblasts.
http://www.ncbi.nlm.nih.gov/pubmed/1350132Retrospective studies in scleroderma: pulmonary findings and effect of potassium p-aminobenzoate on vital capacity.
http://www.ncbi.nlm.nih.gov/pubmed/2602668Retrospective studies in scleroderma: skin response to potassium para-aminobenzoate therapy.
http://www.ncbi.nlm.nih.gov/pubmed/3180546Retrospective studies in scleroderma: effect of potassium para-aminobenzoate on survival.
http://www.ncbi.nlm.nih.gov/pubmed/3257255Potassium para-aminobenzoate and liver function test findings.
http://www.ncbi.nlm.nih.gov/pubmed/3487559Effects of potassium para-aminobenzoate on growth and macromolecule synthesis in fibroblasts cultured from normal and sclerodermatous human skin, and rheumatoid synovial cells.
http://www.ncbi.nlm.nih.gov/pubmed/155125Treatment of scleroderma.
http://www.ncbi.nlm.nih.gov/pubmed/301981———-
Some people have stated that research has shown that Potaba is ineffective. Most likely, this is the study (see below) they’re referring to. I do not believe that such a conclusion is valid since it is based on the results of only one study, especially considering that several previous studies found some evidence of beneficial effects. Also, I noticed that most of the people who participated in the study had scleroderma for a fairly long period of time. I have to wonder whether the results would have been different if the study had been restricted to people with scleroderma of fairly recent onset.
Comparison of aminobenzoate potassium and placebo in the treatment of scleroderma.
http://www.ncbi.nlm.nih.gov/pubmed/8151563Some previous discussion of Potaba on this forum:
New Morphea/SC Med? Brand:”Potaba” [Generic]: “Aminobenzoate Potassium”
https://www.roadback.org/forums/topic/new-morpheasc-med-brandpotaba-genetic-aminobenzoate-potassium/Potaba
https://www.roadback.org/forums/topic/potaba/Potaba vs Neprinol
https://www.roadback.org/forums/topic/potaba-vs-neprinol/Phil
"Unthinking respect for authority is the greatest enemy of truth."
- Albert EinsteinJuly 1, 2012 at 9:14 pm #364218cavalier
ParticipantPronunciation: (poh-TASS-ee-um pair-uh-am-EE-no-BEN-zoh-ate)
Brand name(s): Potaba
Uses
This medication is used to treat certain skin disorders (e.g., dermatomyositis, scleroderma, Peyronie’s disease). It helps make your skin more flexible and softens plaques. Potassium para-aminobenzoate is thought to work by increasing the use of oxygen in the skin.I found this interesting above in increasing oxygen – I am using Hyperbaric O2 as a adjunct to AP along with Peptide injections in covering the bases in treatments that compliment one another. Hypderbaric or HBOT is FDA approved to increase stem cell activity in the very cell level. My hand lesions are still there however they are flatter like the air has been let out of them. My feet are dramatically improved & the lesions on both my feet are gone. 90% of the raynauds is gone what is left is lighter in color. I know this is due to the HBOT as the Lyme had stopped the effectiveness of the minocycline & I got progressively worse in new symptoms & the amount of lesions and areas of my skin, I was told to go off the mino. so while i was stalled this was the only thing I had going for me & I saw dramatic improvements. I am mid way into treatment with HBOT for the initial bigger number of treatments. Anywho – I just thought the correlation was interesting. I am now on a stouter regime of AP for the Lyme and SD plus the above. NO doubt there is a skin softening affect to HBOT and it is showing to be helpful.
Thanks for posting this Phil. best – Jill
December 6, 2016 at 10:10 pm #457238PhilC
ParticipantSince my original post was mostly destroyed by the site migration, I just restored it with an updated version (fixed some broken links).
Phil
"Unthinking respect for authority is the greatest enemy of truth."
- Albert EinsteinDecember 7, 2016 at 8:37 am #457240richie
ParticipantHi Very interesting –should potassium levels be checked if one takes it -I am going to give all your info to someone I know who is really suffering with SD and for a strange reason refuses to try AP —I gave up as this person ts really going down hill and its too aggravating but I will show them this –richie
October 23, 2017 at 3:59 pm #460878Denyse
ParticipantI was on POTBA from Glenwood and it was a huge help in softening my cheek muscles but I had to cut back on recommended dosage as i ended up with extreme anxiety. 1 capsule daily worked for me. Unfortunately I am unable to find it in Canadian Pharmacies abd no longer take it.
CANADIAN LIVING IN CANADA
Diagnosis/ Diffuse Scleroderma since 05/2006
Current Meds: Methotrexate, Minocin, Zantac, Rabeprozale, Zopiclone
Current Supp: Nattokinase, Serrapeptase, COQ10, Milk Thistle, Folate,, B12, D3, Melissa, UP4 probiotics, N-A-C
medical MJ
Current Extras: FIROctober 24, 2017 at 6:26 am #460881PhilC
ParticipantHi Denyse,
You could try taking PABA, since it is very nearly the same thing — Potaba is the potassium salt of PABA.
Phil
"Unthinking respect for authority is the greatest enemy of truth."
- Albert EinsteinOctober 25, 2017 at 12:56 am #460893Denyse
ParticipantYes that is what i take now but the prescription Potaba is more beneficial.
CANADIAN LIVING IN CANADA
Diagnosis/ Diffuse Scleroderma since 05/2006
Current Meds: Methotrexate, Minocin, Zantac, Rabeprozale, Zopiclone
Current Supp: Nattokinase, Serrapeptase, COQ10, Milk Thistle, Folate,, B12, D3, Melissa, UP4 probiotics, N-A-C
medical MJ
Current Extras: FIROctober 25, 2017 at 12:59 am #460894Denyse
Participantalso I have to get it across the border as its unavailable in Canada. Glenwood still makes the prescription Potaba, I contacted them directly and now I just need to find a pharmacy in the US that will supply it.
CANADIAN LIVING IN CANADA
Diagnosis/ Diffuse Scleroderma since 05/2006
Current Meds: Methotrexate, Minocin, Zantac, Rabeprozale, Zopiclone
Current Supp: Nattokinase, Serrapeptase, COQ10, Milk Thistle, Folate,, B12, D3, Melissa, UP4 probiotics, N-A-C
medical MJ
Current Extras: FIR -
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