Home Forums General Discussion OT Plaquenil for CV19

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  • #465544
    Jan Lucinda1
    Participant

    There is talk of plaquenil for CV19. Do you think it could treat a virus? I’m wondering.

    #465545
    Maz
    Keymaster

    Here is some info on how hydroxychloroquinine (Plaquenil) likely works:

    COVID-19: the biology of an effective therapy

    #465546
    Linda L
    Participant

    This is what I meant in the previous topic.
    Maz, I cannot open this page.

    RA tried everything: Methotraxate, Arava, Humira. Pneumonia three times. Anemia. Very low iron. Hypothyroidism
    AP from April 2014 till August 2015. No luck.
    Current medications: Natural thyroid, Mobic, LDN, supplements incl. milk thistle, vitamins and minerals.
    MTHFR heterozygous

    #465547
    Jan Lucinda1
    Participant

    Maz- Plaquenil is antiparasitic. It works on RA which is bacterial. Do you think it will work in a virus also?

    Jan

    #465548
    Maz
    Keymaster

    Hi Linda, try copying the title into your search engine. It may be that because you’re abroad, you can’t open the link provided. It’s opening here okay.

    Jan, if you can manage to get thru the entire article above, it provides the science about how plaquenil is thought to work for COVID-19.

    Many antimicrobisls work for different organisms. E.g., doxy for anti-malarial or cell-wall deficient bacteria. LLMDs commonly use plaquenil to target the cystic form of Lyme, as well as the coinfection, bsbesiosis, and to “alkalize the intracellular compartment” to help other antimicrobials to work. Artemisinin is an anti-malarial but has also been found to target various viruses, like HPV. This is why older meds that are approved for specific diseases are sometimes found useful, years later, like methotrexate, first developed for lymphoma, is now used off-label for RA, and plaquenil was developed for malaria, but due to its anti-inflammatory effects, is also useful for RA. Minocycline was developed for cystic acne, but was later classed as a DMARD. Many meds are repurposed in this way and used for what are called “off-label” purposes when they are studied and found useful for different medical indications. They are already approved by the FDA for safety so can be fast-tracked to be studied for other indications. Plaquenil and azithromycin are now being studied in combo to treat COVID-19. Caution not to put the horse before the cart is being expressed by Fauci, because larger studies need to be completed to be certain, though things are currently looking hopeful for this combo.

    Researchers Look To Old Drugs For A Possible Coronavirus Treatment – It Might Just Work

    #465549
    Jan Lucinda1
    Participant

    I read actor Daniel Day Kim said plaq helped his recovery. Encouraging.

    #465550
    Maz
    Keymaster

    Keeping fingers crossed! 🤞🤞🤞

    #465551
    Linda L
    Participant

    Thank you Mąż, working.

    RA tried everything: Methotraxate, Arava, Humira. Pneumonia three times. Anemia. Very low iron. Hypothyroidism
    AP from April 2014 till August 2015. No luck.
    Current medications: Natural thyroid, Mobic, LDN, supplements incl. milk thistle, vitamins and minerals.
    MTHFR heterozygous

    #465552
    Maz
    Keymaster
    #465729
    Jan Lucinda1
    Participant

    Trump is on hydroxychlorouine.

    #465774
    Linda L
    Participant

    Plaquenil has been banned in France.

    RA tried everything: Methotraxate, Arava, Humira. Pneumonia three times. Anemia. Very low iron. Hypothyroidism
    AP from April 2014 till August 2015. No luck.
    Current medications: Natural thyroid, Mobic, LDN, supplements incl. milk thistle, vitamins and minerals.
    MTHFR heterozygous

    #465775
    Maz
    Keymaster

    Not in Italy!

    Italian scientist says she discovered main mechanism behind COVID-19 By MAAYAN JAFFE-HOFFMAN MAY 3, 2020

    “The Italian Society of Rheumatology interviewed 1,200 rheumatologists throughout Italy to collect statistics on contagions. Out of an audience of 65000 chronic lupus and rheumatoid arthritis patients who systematically take hydroxychloroquine, only 20 tested positive for the virus. “Nobody died, nobody is intensive care, according to the data collected so far,” Chiosulo said.”

    The issue with Hydroxychloroquine and Covid-19 is that patients were told not to go to hospital unless they were unable to breathe. Many Covid patients are hypoxic by that stage with blood oxygen levels dangerously low, putting terrible strain on the cardiovascular system and other organs. Studies on Covid-19 are taking place in hospitals and hydroxychloroquine was being used on the sickest of sick patients about to be or on ventilators when prognosis is very poor. These studies were doomed to fail.

    It’s very interesting that in 7 decades of hydroxychloroquine use, not one cardiology society has weighed in on the cardiac dangers of this med! It’s safety track record as one of the safest DMARDs for use in RA and lupus is pretty exemplary. Clearly it shouldn’t be used in very sick hypoxic patients with blood clots in their circulatory system but the retrospective Italian study on RA and lupus patients, a country that was hit very hard by the virus, it seems hard to deny that this patient population was afforded some protection taking it as a DMARD.

    #465776
    Lynne G.SD
    Participant
    #465777
    Maz
    Keymaster

    Some research-physicians are also questioning the possibility of a re-activation, from viral immune suppression, of a co-existent coinfection, such as chlamydia pneumoniae, known to exist in a chronic cryptic (dormant) form in the human body and causing multi-systemic inflammatory symptoms.

    Co-existence of coronavirus with bacterial pathogen a major cause of fatalities

    #465782
    Linda L
    Participant

    Thank you Lynne and Maz. What a shame

    RA tried everything: Methotraxate, Arava, Humira. Pneumonia three times. Anemia. Very low iron. Hypothyroidism
    AP from April 2014 till August 2015. No luck.
    Current medications: Natural thyroid, Mobic, LDN, supplements incl. milk thistle, vitamins and minerals.
    MTHFR heterozygous

Viewing 15 posts - 1 through 15 (of 22 total)

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