Home Forums General Discussion Potaba for fibrosis

This topic contains 7 replies, has 4 voices, and was last updated by  Denyse 1 month, 3 weeks ago.

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  • #306874
    PhilC
    Participant

    I recently did some research on this drug and thought I’d post what I found.

    Information from the manufacturer:

    Potaba ® (Potassium p-Aminobenzoate) – Patient Information
    http://www.glenwood-llc.com/potaba.html

    Potaba ® (Potassium p-Aminobenzoate) – Prescribing Information
    http://www.glenwood-llc.com/pre-potaba.html

    Relevant research:

    A comparison of morphoea and lichen sclerosus et atrophicus in vitro: the effects of para-aminobenzoate on skin fibroblasts.
    http://www.ncbi.nlm.nih.gov/pubmed/1350132

    Retrospective studies in scleroderma: pulmonary findings and effect of potassium p-aminobenzoate on vital capacity.
    http://www.ncbi.nlm.nih.gov/pubmed/2602668

    Retrospective studies in scleroderma: skin response to potassium para-aminobenzoate therapy.
    http://www.ncbi.nlm.nih.gov/pubmed/3180546

    Retrospective studies in scleroderma: effect of potassium para-aminobenzoate on survival.
    http://www.ncbi.nlm.nih.gov/pubmed/3257255

    Potassium para-aminobenzoate and liver function test findings.
    http://www.ncbi.nlm.nih.gov/pubmed/3487559

    Effects of potassium para-aminobenzoate on growth and macromolecule synthesis in fibroblasts cultured from normal and sclerodermatous human skin, and rheumatoid synovial cells.
    http://www.ncbi.nlm.nih.gov/pubmed/155125

    Treatment of scleroderma.
    http://www.ncbi.nlm.nih.gov/pubmed/301981

    ———-

    Some people have stated that research has shown that Potaba is ineffective. Most likely, this is the study (see below) they’re referring to. I do not believe that such a conclusion is valid since it is based on the results of only one study, especially considering that several previous studies found some evidence of beneficial effects. Also, I noticed that most of the people who participated in the study had scleroderma for a fairly long period of time. I have to wonder whether the results would have been different if the study had been restricted to people with scleroderma of fairly recent onset.

    Comparison of aminobenzoate potassium and placebo in the treatment of scleroderma.
    http://www.ncbi.nlm.nih.gov/pubmed/8151563

    Some previous discussion of Potaba on this forum:

    New Morphea/SC Med? Brand:”Potaba” [Generic]: “Aminobenzoate Potassium”
    http://www.roadback.org/forums/topic/new-morpheasc-med-brandpotaba-genetic-aminobenzoate-potassium/

    Potaba
    http://www.roadback.org/forums/topic/potaba/

    Potaba vs Neprinol
    http://www.roadback.org/forums/topic/potaba-vs-neprinol/

    Phil

    "Unthinking respect for authority is the greatest enemy of truth."
    - Albert Einstein

    #364218
    cavalier
    Participant

    Pronunciation: (poh-TASS-ee-um pair-uh-am-EE-no-BEN-zoh-ate)
    Brand name(s): Potaba
    Uses
    This medication is used to treat certain skin disorders (e.g., dermatomyositis, scleroderma, Peyronie’s disease). It helps make your skin more flexible and softens plaques. Potassium para-aminobenzoate is thought to work by increasing the use of oxygen in the skin.

    I found this interesting above in increasing oxygen – I am using Hyperbaric O2 as a adjunct to AP along with Peptide injections in covering the bases in treatments that compliment one another. Hypderbaric or HBOT is FDA approved to increase stem cell activity in the very cell level. My hand lesions are still there however they are flatter like the air has been let out of them. My feet are dramatically improved & the lesions on both my feet are gone. 90% of the raynauds is gone what is left is lighter in color. I know this is due to the HBOT as the Lyme had stopped the effectiveness of the minocycline & I got progressively worse in new symptoms & the amount of lesions and areas of my skin, I was told to go off the mino. so while i was stalled this was the only thing I had going for me & I saw dramatic improvements. I am mid way into treatment with HBOT for the initial bigger number of treatments. Anywho – I just thought the correlation was interesting. I am now on a stouter regime of AP for the Lyme and SD plus the above. NO doubt there is a skin softening affect to HBOT and it is showing to be helpful.

    Thanks for posting this Phil. best – Jill

    #457238
    PhilC
    Participant

    Since my original post was mostly destroyed by the site migration, I just restored it with an updated version (fixed some broken links).

    Phil

    "Unthinking respect for authority is the greatest enemy of truth."
    - Albert Einstein

    #457240
    richie
    Participant

    Hi Very interesting –should potassium levels be checked if one takes it -I am going to give all your info to someone I know who is really suffering with SD and for a strange reason refuses to try AP —I gave up as this person ts really going down hill and its too aggravating but I will show them this –richie

    #460878
    Denyse
    Participant

    I was on POTBA from Glenwood and it was a huge help in softening my cheek muscles but I had to cut back on recommended dosage as i ended up with extreme anxiety. 1 capsule daily worked for me. Unfortunately I am unable to find it in Canadian Pharmacies abd no longer take it.

    CANADIAN LIVING IN CANADA
    Diagnosis/ Diffuse Scleroderma since 05/2006
    Current Meds: Methotrexate, Minocin, Zantac, Rabeprozale, Zopiclone
    Current Supp: Nattokinase, Serrapeptase, COQ10, Milk Thistle, Folate,, B12, D3, Melissa, UP4 probiotics, N-A-C
    medical MJ
    Current Extras: FIR

    #460881
    PhilC
    Participant

    Hi Denyse,

    You could try taking PABA, since it is very nearly the same thing — Potaba is the potassium salt of PABA.

    Phil

    "Unthinking respect for authority is the greatest enemy of truth."
    - Albert Einstein

    #460893
    Denyse
    Participant

    Yes that is what i take now but the prescription Potaba is more beneficial.

    CANADIAN LIVING IN CANADA
    Diagnosis/ Diffuse Scleroderma since 05/2006
    Current Meds: Methotrexate, Minocin, Zantac, Rabeprozale, Zopiclone
    Current Supp: Nattokinase, Serrapeptase, COQ10, Milk Thistle, Folate,, B12, D3, Melissa, UP4 probiotics, N-A-C
    medical MJ
    Current Extras: FIR

    #460894
    Denyse
    Participant

    also I have to get it across the border as its unavailable in Canada. Glenwood still makes the prescription Potaba, I contacted them directly and now I just need to find a pharmacy in the US that will supply it.

    CANADIAN LIVING IN CANADA
    Diagnosis/ Diffuse Scleroderma since 05/2006
    Current Meds: Methotrexate, Minocin, Zantac, Rabeprozale, Zopiclone
    Current Supp: Nattokinase, Serrapeptase, COQ10, Milk Thistle, Folate,, B12, D3, Melissa, UP4 probiotics, N-A-C
    medical MJ
    Current Extras: FIR

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