anti-ccp

[Anonymous]

My anti-ccp is 169  and the normal is below 60(i think). Does that mean that my joint erosion would be quick and swift.  I am taking mino 2*100mg daily.

 

thanks/ gupta

[Maz]

Hi Gupta,

Like you, my anti-CCP is somewhere above 60…my lab (Quest) doesn't give the exact number, just 60 as an upper limit, so I have no idea how high it is.

While RF can be elevated in any number of rheumatoid conditions and even in people who have no symptoms at all, the anti-CCP is considered to be confirmation of an RA dx, as well as a prognostic indicator of severity. The higher it is, the higher the chance for joint degeneration. That said, however, a small percentage of people also test false positive for anti-CCP, so there is really no guarantee either way. What seems to be consistant for me is the RF reading, which better reflects how I am feeling in present time. I get my bloodwork done every month or so and as I've improved, so has my RF declined (from mid 500s to mid 50s now). Anti-CCP in my personal experience, on the other hand, seems to be less sensitive in this regard and, from what I understand, can take longer to come down, in spite of physical improvement.

You might take heart, as I do, in knowing that others here on the BB have reported that their anti-CCP has come down over time while on AP, so it's not a static number, per say.

How long have you been on 100mg bid of mino? Are you seeing any improvements in your RA?

Peace, Maz

[Tiff]

Hi Gupta,

Maz covered it pretty well.  I just wanted to say I also have had a similar experience, but unlike most folks I have seen on this board, I have been very low with my RF while having a high CCP.  At one time it was 194, but 6 months on AP and it dropped to 94.  I've had PRA (a form of RA) for nearly 3 years.  As of last summer there was no indication of joint damage yet.  I'm also on daily Minocin.  It isn't working well for me, so I will be starting a different protocol after spring break.  Keep in touch.

 

[Lizz]

Gupta, it's all individual. I'm sero-negative and last check my anti-ccp was 68. I've had it bad in my right knee for two and a half years, yet the latest X-ray showed no damage ( only some osteo). Even my rhummey, who usually touts Enebrel or Plaquenil, said I was holding my own. I've been on minocin for 11 months, did daily dosing for a few months and then recently switched to M,W, F . You've got to do what's right for you and I would never personally ignore the joint damage issues, especially if it was going to affect my livlihood. Keep listening to all these wonderful people, they have been my lifeline, and I wish you smoother sailing in the weeks to come!

[Author]

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